Исполнители
Marilyn Manson – arp, bass, composer, drums (electric, syncussion) (2) , guitar (rhythm), photography, piano, production, synthesizer, vocals (lead, background), vocoder
Zim Zum - composer, guitar (1,3,5-7,9-10,14) synthesizer, keyboards
Twiggy Ramirez – composer, bass, guitar, noise, clavinet
Ginger Fish – drums (live, electric), vocals, vocoder
M.W. Gacy - composer, drums (14), drums (electric), keyboards Mellotron, piano (2-3), sampling, shaker, synthesizer, Bass (13)
John 5 - live guitarist for Mechanical Animals
Приглашенные исполнители:
Dave Navarro - гитара в I Don't Like the Drugs (But the Drugs Like Me)
Danny Saber – клавишные, клавинет
Rose McGowan - вокал в Posthuman
Alexandra Brown - бэк-вокал в I Don't Like the Drugs (But the Drugs Like Me)
Lynn Davis - бэк-вокал в I Don't Like the Drugs (But the Drugs Like Me)
Dyanna Lauren - "pornography" on "New Model No.15"
John West - бэк-вокал в I Don't Like the Drugs (But the Drugs Like Me)